SMAD3 and cardiac hypertrophy: The association between the effects of tamsulosin treatment on the infarcted heart in rat model of ISO-induced MI and the protein levels of ILK/TGF-/p-Smad2/Smad3 has not yet been established, even though the multifunctional effector ILK is linked to integrin receptors and has been demonstrated to actively promote cardiac hypertrophy while interacting synergistically with other hypertrophic stimuli such as the α-adrenergic agonist phenylephrine.