The key findings of the present study include the following: (1) increased adiponectin mRNA expression from LV epicardial adipose tissue was associated with reduced LV systolic function, whereas elevation of both resistin and RBP4 mRNA expression from LV epicardial adipose tissue was linked with decreased LV diastolic function; (2) the regional epicardial adipose tissue mRNA expression of resistin, RBP4, and adiponectin did not differ between individuals with CAD of the corresponding coronary artery and those without CAD. Here, RBP4 is linked to coronary artery disorder.