Here, we showed a significant increase in NPX in 6 proteins (alpha-2-MRAP, HAGH, Siglec-9, MDGA1, EDA2R, and IL12) in the l-GCF group of older adults with overweight/obesity and MetS from the PREDIMED-Plus cohort. This evidence concerns the gene HAGH and obesity due to melanocortin 4 receptor deficiency.