Among the factors investigated, those associated with the highest mean number of pregnancy losses, in a decrescent order of magnitude, were cervical isthmic incompetence, anti-beta-2- glycoprotein-1 antibodies, unicornuate uterus, anti-Prothrombin A antibodies, protein C deficiency, and LAC. Here, APOH is linked to hyperinsulinemic hypoglycemia, familial, 4.