TP53 and cancer: To examine whether GOF and non-GOF mutations have different effects on the gene expression profile of the p53 signaling pathway, the gene expression ratios of the GOF mutant group to the TP53 wild-type group and the non-GOF mutant group to the TP53 wild-type group were calculated for each gene by cancer types in cohort B. Then, we performed a cross-cancer unsupervised hierarchical cluster analysis using the calculated gene expression ratios.