TP53 and cancer: To examine whether the changes in the gene expression profile of the p53 signaling pathway caused by TP53 mutations differ among cancer types, we performed a cross-cancer unsupervised hierarchical cluster analysis using the gene expression ratios of the p53 signaling pathway in cohort A. As a result, the 21 cancer types in cohort A were classified into clusters comprising 17 (cluster A1) and 4 (cluster A2) cancer types.