MLC1 and lymphoma: Aiming to develop a highly specific rabbit-derived VL sdAb against cNHL, a whole-cell rabbit immunization strategy, antibody library construction, and phage display selection were performed, as depicted in Fig. 1B. To induce a strong and specific immune response against cNHL receptors, one female New Zealand rabbit was immunized with a pool of two isolated cNHL primary cells (ID5 and ID6) from a canine multicentric lymphoma biobank previously established and characterized by our group34.