In the classification of the World Health Organization (WHO) in 20081, genomic features such as fusion genes, including PML-RARA, RUNX1-RUNX1T1, DEK-NUP214, CBFB-MYH11, and mutations of CEBPA and NPM1, determined molecular subtypes in adult AML. The gene discussed is PML; the disease is acute myeloid leukemia.