Three patients with high HRDetect (cholangiocarcinoma, colorectal cancer, stomach adenocarcinoma) did not have pathogenic mutations in HR genes, although the whole-genome sequencing data revealed a benign homozygous germline mutation in ATM and a somatic variant of unknown significance in RBBP8 in the patient with intrahepatic cholangiocarcinoma and a benign germline mutation in BRCA1 in the patient with stomach adenocarcinoma. The gene discussed is BRCA1; the disease is colorectal cancer.