We also observed a significant reduction in both the level of Bcl-6 protein expression and frequency of NP-specific Bcl-6+ cells in Aiolos-deficient CD4+ T cells at an early timepoint post-infection, supporting a role for Aiolos in the positive regulation of Bcl6 expression in vivo (Supplementary Fig. 3d). The gene discussed is BCL6; the disease is infection.