CD8A and acute myeloid leukemia: Conversely, both CD8+ T cells and NK cells from AML patients were reinvigorated in their ability to respond to PMA plus ionomycin upon depletion of malignant blasts, and even more so depletion of malignant blasts combined with rIFNs administration (Fig. 2F, G), although the effect on IFN-γ synthesis was less pronounced on CD8+ T cells than on NK cells.