To this aim, we compared the phosphorylation status of the TLR3 signal transducer TANK binding kinase 1 (TBK1) in 3 patients with AML exhibiting lower-than-median IFN-i (IFN-i Lo) vs 3 patients with AML exhibiting higher-than-median IFN-i (IFN-iHi) from Study Cohort 1 by immunoblot analyses (Supplemental Table 5). The gene discussed is TBK1; the disease is acute myeloid leukemia.