While in cBCC we observed the reduced expression of PSAT1, SHMT1, MTHFR, MTHFD1. To expand these results, we interrogated a publicly available dataset (GSE7553) of cBCC (n = 15), cSCC (n = 11) and normal skin (n = 4) as the healthy control. Here, MTHFR is linked to skin squamous cell carcinoma.