NOD2 and Alzheimer disease: Intracellular NLRs, including NOD1, NOD2, NLRP1, NLRP3, NLRP4, and the interferon-inducible protein AIM2 produce a series of inflammatory molecules to resist the invasion of microorganisms.424 NOD2 is considered a major player in innate immune response to S. aureus in the skin.425 Studies have found that NOD2 expression on basophils in the peripheral blood of AD cases is markedly reduced compared with that of healthy people,426 and basophils are the main effector cells involved in Th2 polarization in allergic inflammation.