Airway inflammation in eosinophilic allergic asthma features infiltrated and activated eosinophils, and co-culture of epithelial cells with mast cells or eosinophils induce NF-κB-dependent cytokine production by airway epithelial cells.215,216 NF-κB signaling is critical in the survival of eosinophils, exerting an anti-apoptotic effect through autocrine TNF-α.217 NF-κB suppressors on the other hand, including MG-132, reduce eosinophil amounts and alleviate allergic inflammation.218. The gene discussed is NFKB1; the disease is allergic asthma.