Twin studies revealed that FA had high heritability, and GWAS and candidate gene studies indicated marked associations of the human leukocyte antigen(HLA)-DR and HLA-DQ region with genetic variants in multiple genes, including Filaggrin (FLG), the HLA locus, and Forkhead Box Protein P3 (FOXP3).39 Peanut allergy in 82% of identical twins far exceeds the 20% concordance rate observed in dizygotic twins,40,41 further supported by the fact that children whose parents or siblings have peanut allergy are 7 times more likely to develop the disease compared with children without family risk factors. The gene discussed is FLG; the disease is peanut allergic reaction.