MPIG6B and allergic asthma: The IgE receptor FcɛRI highly contributes to the development and remodeling of airway inflammation in allergic asthma.319 Studies in animals with experimental allergic asthma demonstrated that when the vagus nerve, which dominates the airway, senses the invasion of allergens, pain receptor neurons overexpress the immunoglobulin receptor FcɛRI and release Substance P, which drives the polarization of Th2 cells, thus triggering allergic inflammation.320