MTOR and allergic disease: mTOR has catalytic subunits in two different complexes, including mTOR complex 1 (mTORC1) and mTORC2,298 which have different susceptibilities to rapamycin, substrates, and functions.299 Studies in allergic diseases have shown that mTOR is a key molecule for sensing the immune microenvironment and determining the function and differentiation of immune cells,300 because it regulates a variety of immune cells and limits pro-inflammatory mediators.301,302 For example, increasing evidence supports that mTOR is an important regulator of Tfh cell differentiation.