Among them, eosinophils regulate Th2 immune response, which is related to the severity of the disease,305 while ablation of mTOR leads to Gata-1 overexpression and increases eosinophil differentiation.306 The angiogenic factor fibroblast growth factor-binding protein 1 (FGFBP1) is highly expressed in asthma models with airway remodeling features, because activating mTORC1 and signal transducer and activator of transcription 3 (STAT3) signaling pathways enhances FGFBP1 expression and secretion, thus inducing angiogenesis.307. The gene discussed is STAT3; the disease is asthma.