USH2A-CT(S) binds to WHRN NPDZ12 T110A with a weaker binding affinity (Kd = ~16 μM) than that of the WT (Kd = ~2.7 μM), which may contribute to deafness (Fig. 8b and Supplementary Fig. 8a). This evidence concerns the gene USH2A and deafness.