BET proteins are members of a bromodomain subfamily including BRD2~4 and BRDT, which mediate histone acetylation recognition, chromatin remodeling, and transcription regulation, therefore regulating inflammation, apoptosis, cell proliferation, the cell cycle, and cancer.98 In addition to enhancing the transcription of NF-κB-dependent proinflammatory cytokine genes, BET proteins also regulate the STAT signaling pathway.98 The gene discussed is NFKB1; the disease is cancer.