Beyond directly accelerating PC development by providing excessive glucose to cancer cells, hyperglycemia also promotes cell proliferation via the induction of epidermal growth factors (EGFs) and their receptors (EGFRs) while causing endothelial dysfunction and promoting angiogenesis.98 In addition, multiple signaling pathways can be aberrantly activated in hyperglycemia. The gene discussed is EGF; the disease is Hyperglycemia.