METTL13 and pachyonychia congenita: In Ras-driven cancers such as PC, the guanosine triphosphatase (GTPase) activity of eukaryotic elongation factor 1A (eEF1A) catalytically increased by methyltransferase-like 13 (METTL13) augments protein production in vitro, and METTL13 dimethylation of eEF1A lysine 55 (eEF1AK55me2) enhances translation and protein synthesis to promote carcinogenesis in vivo.134