In Ras-driven cancers such as PC, the guanosine triphosphatase (GTPase) activity of eukaryotic elongation factor 1A (eEF1A) catalytically increased by methyltransferase-like 13 (METTL13) augments protein production in vitro, and METTL13 dimethylation of eEF1A lysine 55 (eEF1AK55me2) enhances translation and protein synthesis to promote carcinogenesis in vivo.134. Here, EEF1A1 is linked to pachyonychia congenita.