WAT inflammation is also associated with elevated circulating levels of various adipokines, C-reactive protein (CRP), and IL-6 in patients with obesity and DM, which have all been shown to promote pancreatic carcinogenesis.254–256 Therefore, it is likely that both the local and systemic environments are reprogrammed to promote carcinogenesis under conditions of WAT dysfunction and inflammation. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.