CD8A and pachyonychia congenita: It was suggested that a higher number of DCs, whether in the circulation or within the tumor, is correlated with longer survival, regardless of the stage of PC at diagnosis.415 Of note, the number of DCs infiltrated within the tumor is parallel to the number of CD4+ and CD8+ T cells in patients with PDAC, implying the presence of all key components in the antitumor immune response, and the decreased number and function of DCs in PDAC is responsible for the immune tolerance resulting from compromised antigen presentation.415