HIF1A and pachyonychia congenita: In addition to its potential correlations with inflammatory TLRs in PanIN lesions,347 HIF-1α can also promote pancreatic carcinogenesis by regulating the expression of EMT-related genes336 and its downstream target retention in endoplasmic reticulum sorting receptor 1 (RER1).348 Additionally, the transcriptional activity of HIF-1α has also been shown to be correlated with the number of TICs in PC.349