RBP4 and hypertensive disorder: RBP-4 is an adipocytokine that acts by binding to cell surface receptors or through retinoic acid and retinoic acid-X receptors and is associated with TAG, total cholesterol, and LDL-cholesterol dysregulation and high blood pressure.236 Although some have questioned the diagnostic specificity of RBP4 in PC,299 others have shown that increased RBP-4 is effective in discriminating PC in patients with T2DM.300 Consistently, RBP-4 was suggested to promote JAK/STAT signaling via its receptor stimulated by retinoic acid 6 (STRA6) in carcinogenesis.236