In addition, oxy186, a semisynthetic oxysterol analog as an inhibitor of Hedgehog (Hh) signaling acting downstream of Smoothened (Smo), was illustrated to suppress Hh signaling and the proliferation of PANC-1 cells.85 Finally, oxysterol binding protein-related protein 5 (ORP5) induces the expression of SREBP-2 to enhance the cholesterol synthesis pathway and activates histone deacetylase 5 (HDAC5) to promote the growth of PC cells.86 The gene discussed is HDAC5; the disease is pachyonychia congenita.