In settings where the probability of co-infection is higher, there may be an impact on the timing of events depending on the prevalence of non-malarial fevers tested by RDT, the prevalence of HRP2-negative parasites and the multiplicity of infection in hosts, but it is unlikely that the overall patterns observed following a change in RDT, and the relative comparisons between scenarios would be impacted. Here, HDGFL2 is linked to coinfection.