LPCAT1, an enzyme found significantly upregulated in inflamed tissue samples, was described to be upregulated upon gut microbiome dysregulation.69 The main substrates consumed by LPCAT1, lysophosphatidylcholines [n = 14 distinct molecules] were found significantly downregulated in the plasma of colitis patients [Supplementary Table S2]. Here, LPCAT1 is linked to colitis.