Plasmid clusters either variably or always carrying blaTEM-1 were strongly associated with BSI (p<0.01, Chi-squared test X2=8.19, 33/161 of BSI clusters containing blaTEM-1 vs. 5/86 for non-BSI clusters) and carried a higher number of other AMR genes (p<0.01, Wilcoxon text of blaTEM-1-plasmid clusters vs. others; see Appendix 1—figure 7). The gene discussed is ACKR5; the disease is bathing suit ichthyosis.