TNF and scrub typhus: Luce-Fedrow et al. [61] found triple- (IFN-γ+TNF+IL-2) and double- (IFN-γ+IL-2) cytokine-producing CD4+ T cells with no polyfunctional CD8+ T cell signature in a lethal mouse model of scrub typhus ((Karp, intraperitoneal (IP)).