TENM2 and non-Hodgkin lymphoma: However, we observed significant hypomethylation (p<0.05) of the TENM2 promoter region (host gene of 3_nv_chr5_168090507 miRNA) using assay I; 1 CG dinucleotide (Fig 5A and 5B) in cHL cell lines (mean methylation level 9%: range: 3–15%; sd = 5) compared to NHL cell lines (mean methylation level: 57.5% range: 13–77%; sd = 21).