Our previous work indicates that MBD2 mediates Th17 differentiation in a severe asthma mouse model through different cytokines [7, 9, 41], with further investigations revealing that MBD2 and Th17 are increased in the peripheral blood of severe asthma patients, while MBD2 was positively correlated with Th17, which indicates that MBD2 is a potential novel biomarker for identifying severe asthma with different endotypes [42]. The gene discussed is MBD2; the disease is asthma.