Ly6g (neutrophil-specific antibody) (Fig. 5G,H), ECP (eosinophil cationic protein) (Fg. 5I,J) immunohistochemistry and BALF showed the same results, which indicated that neutrophil infiltration was dominant in severe asthma and miR-146a-3p could decrease inflammatory cell levels. The gene discussed is RNASE3; the disease is asthma.