Meanwhile, after irritation with HL and transfected mimic miR-146a-3p, the percentage of Th17-positive cells significantly decreased and further decreased after simultaneous transfection with si-MBD2 (p < 0.05) and increased after being simultaneously transfected with OE-MBD2 (p < 0.01) (Fig. 4D,E). This evidence concerns the gene MBD2 and Hodgkins lymphoma.