Recent genetic sequencing studies in large series of predominantly childhood medulloblastoma have implicated loss-of-function, predominantly truncating, variants in the ELP1 (mean age of onset = 6.5years accounts for 3.2% of cases) and GPR161 (mean age of onset = 1.5years; accounts for 0.38% of cases) genes[4,5-Table 1] in causation of the MBSHH subtype specifically. The gene discussed is GPR161; the disease is medulloblastoma.