There were no statistically significant differences for HLA-DR, Osteopontin, CD81, CD106, and HBEGF between severe malaria and the rest of the malaria cohort (Figure S4a), which might be due to the small group size for the severe malaria patients (n = 3), though trends of subtle up- (CD81) or down-regulation (HLA-DR) could be observed. This evidence concerns the gene HBEGF and malaria.