Further studies showed that miR-124 could directly regulate the expression of CLOCK by binding to 3`UTRs, and it was precisely because of the abnormal expression of miR-124 that the expression of circadian rhythm gene CLOCK was abnormally elevated, which in turn enhanced the activity of NF-κB and therefore promoted the migration of glioma cells (Li et al. 2013). Here, CLOCK is linked to central nervous system cancer.