EPHA2 and central nervous system cancer: Similarly, both in glioma specimens and glioma cell lines, the expression of miR-124 was also down-regulated, while the direct regulatory target genes, such as the calcium protease subunit 1 (Capn 4) (Cai et al. 2015), the fos-related antigen 2 (Fra-2) (Luo et al. 2018), and ephrin-A receptor 2 (EphA2) (Wu et al. 2018) were aberrantly highly expressed, which could enhance the migration ability of the glioma cells.