Furthermore, well-known core fucosylated cancer biomarkers α-fetoprotein (AFP) and α–1-antitrypsin (A1AT), both >50 kDa, displayed systemic elevation in LC patient sera following osimertinib treatment and in secretomes of drug-stressed cells and DR clones, at least those expressing basal A1AT (Figure 1—figure supplement 10A and B). Here, SERPINA1 is linked to cancer.