EGFR and neoplasm: In xenograft tumor tissues, gene expression profiling showed variable FUT expressions but a unanimous marked increase in FUK-FPGT, FUT8, and SLC35C1 expressions associated with EGFR-TKI resistance (Figure 1—figure supplement 11F), reiterating the involvement of fucose salvage pathway in the systemic core fucosylation changes associated with TIS and EGFR-TKI resistance.