Recent studies have shown that APOBEC3B expression is repressed by the DREAM complex (which is composed of Rb-family proteins and E2F transcription factors Starrett et al., 2019) and, accordingly, we found that APOBEC3B is more highly expressed in BKPyV-positive tumors compared to normal tissues and tumors without tumor virus sequences, likely due to LTag activity. This evidence concerns the gene RB1 and neoplasm.