Prior studies have revealed that lncRNAs may function as potential biomarkers for the diagnosis and prognosis of sepsis, such as the well-known lncRNAs NEAT1 and MALAT1.[14,22,23] Herein, we discovered that the relative expression of lncRNA RP11-284N8.3 was remarkably decreased in adults with sepsis compared to that in HCs, which suggested that lncRNA RP11-284N8.3 were closely correlated with sepsis. Here, MALAT1 is linked to Sepsis.