NOTCH3 and CADASIL: CADASIL mainly affects young and middle-aged people, with recurrent subcortical ischemic stroke, migraine, cognitive and affective disorders, and epilepsy as the main clinical manifestations.[7] CADASIL can be disagnosed by the presence of mutations on 23 exons of NOTCH3 gene or deposition of GOM or NOTCH protein in arteriolar smooth muscle.[8]