The results suggested that PPM1M was positively associated with immune-activating and immune-suppressing genes of depleted T cells in pan-cancer, including ENTPD1, CD48, CD28, CD86, HAVCR2, TIGIT, PDCD1, LAG3, CTLA4, and CD96 (Fig. 11A and B). This evidence concerns the gene HAVCR2 and cancer.