The expression of PPM1M was downregulated in glioblastoma multiforme (GBM) (P < .01), colon adenocarcinoma (COAD), brain lower-grade glioma (LGG), pancreatic adenocarcinoma (PAAD), and rectal adenocarcinoma (READ) (P < .05). The gene discussed is PPM1M; the disease is rectum adenocarcinoma.