Molecular pathology features: According to the European Neuro-Oncology Association guidelines for the diagnosis of immunocompetent primary lymphomas, the immunohistochemical features of diffuse large B-cell lymphoma of the central nervous system are marked by CD10, CD19, CD20, PAX-5, BCL-6, MUM1.[2]. Here, PAX5 is linked to diffuse large B-cell lymphoma.