Determined the dynamics of hypoxia-inducible factor 1α (HIF-1α) protein levels in mice, an indicator of tissue hypoxia, after 2 days and 2 weeks of FD, and compared to controls, form-deprivation myopia (FDM) had significantly higher scleral HIF-1α levels compared to controls, and increased axial elongation was observed after 2 weeks. Here, HIF1A is linked to myopia.