Used microarray-based pathological myopia gene expression profiles to identify differentially expressed genes and cultured HSFs under hypoxic conditions, and showed that HIF-1α reduced miR-150-5p expression and promoted LAMA4-mediated activation of the p38 MAPK signaling pathway, which prevented extracellular matrix degradation in HSFs, ultimately leading to myopia.[17] In another experiment, guinea pigs were randomly divided into 2 groups (30 guinea pigs in each group): FDM group and control group (without any treatment). This evidence concerns the gene LAMA4 and myopia.