Various core ingredients in the formula, such as quercetin, kaempferol, naringenin, and licorice chalcone A, may act on STAT3, HIF1A, STAT1, AKT1, CCND1, and other potential key targets and then exert synergistic effects on multiple signaling pathways such as AGE-RAGE signaling pathway, PI3K-Akt signaling pathway and HIF-1 signaling pathway in lipid and atherosclerosis, diabetic complications. Here, RENBP is linked to atherosclerosis.