Studies have shown that a persistent hyperglycemic state will cause plasma protein glycosylation, and insulin glycosylation can distort insulin signaling[29] and reduce insulin sensitivity to adipocyte cell membrane surface receptors,[30] which will cause hyperlipidemia and atherosclerosis manifestations in the long-term[31] and aggravate the risk of T2DM complications. This evidence concerns the gene INS and atherosclerosis.