VDR and neoplasm: Hence, the treatment tested in the co-clinical trial includes a stromal-directed agent (vitamin D receptor ligand) because earlier studies have shown that the activation of vitamin D receptors on stromal cells using synthetic vitamin D such as Paricalcitol reprograms the dense stroma in PDA, leading to decreased fibrosis, increased delivery of gemcitabine, and delayed tumor growth in animal models [52].