Clinically, this is detected only during the partial remission (PR) phase, called the “honeymoon phase”, a stage experienced by up to 80% of pediatric patients with T1D after the initiation of insulin therapy and that is characterized by low requirements of exogenous insulin and diminished glycated hemoglobin (HbA1c) levels [4]. The gene discussed is INS; the disease is type 1 diabetes mellitus.