In the rescue experiments, the inhibition effect of circ‐Bnc2 on neuroinflammation in microglia cells and apoptosis in neuron cells could be reversed by overexpressing miR‐497a‐5p, confirming that circ‐Bnc2 targeted miR‐497a‐5p to alleviate depression progression. Here, BNC2 is linked to depressive disorder.