For instance, TP63 is a master transcription factor that leads to the onset of squamous cell carcinoma, and, together with coactivators, such as bromodomain-containing protein 4 (BRD4), forms a SE consisting of giant molecular assemblies, and TP63 itself is reported to be induced by the SE [18, 19]. This evidence concerns the gene BRD4 and squamous cell carcinoma.