Cytosolic Ca2+ function as intracellular signaling messengers and are involved in cytoskeleton rearrangement, metastasis, metabolism, cell death, and cancer development.[15, 16, 17, 18] An important mechanism for maintaining intracellular Ca2+ levels is store‐operated Ca2+ entry (SOCE), which is mediated by Orai1 Ca2+ channels in plasma membrane (PM)[19, 20] and stromal interaction molecule (STIM) proteins[21] in the endoplasmic reticulum (ER). This evidence concerns the gene ORAI1 and cancer.