After removing the influence of rs1385492, we found that there was a correlation between OPG and AMI/CHD (AMI: weighted median OR = 0.818;95% CI = 0.724–0.950; p = 0.001; 6SNPs;CHD: weighted median OR = 0.842; 95% CI = 0.755–0.938; p = 1.893 × 10−3; 6SNPs). Here, TNFRSF11B is linked to coronary artery disorder.