CD8A and central nervous system cancer: High level of LGALS9 is an indicator of bad prognosis for all stages of glioma (Liang et al., 2019) It should be noted that LGALS9/TIM3 signaling pathway regulates T cell functions in several different ways such as regulation of apoptosis in CD4+ T cells and functional exhaustion of CD8+ T cells (Wang et al., 2020).