GBM uses several ways to establish and cement immune suppressive conditions: it can recruit cells secreting anti-inflammatory cytokines; (Waziri et al., 2008; Tamai et al., 2022), or it overexpresses ligands of immune inhibitory receptors such as PD-L1, HLA-E/HLA-G on the surface (Mittelbronn et al., 2007; Wiendl et al., 2002; Jacobs et al., 2009). Here, CD274 is linked to glioblastoma.