A novel somatic heterozygous missense variant, KCNJ5 c.503T > G (p.L168R), was detected in the left adrenal adenoma, whereas no germline and somatic variants associated with PA and CS were found in the peripheral blood samples or right adrenocortical adenoma (Figures 4A–C). The gene discussed is KCNJ5; the disease is adrenal cortex adenoma.