This report found that the effect of Rg1 on autophagy in T1D mice may be related to CXCL16 and NF-κB. A study reported that the incretion of ox-LDL sensitized adipocytes to the lower insulin-induced glucose uptake and increased the levels of NF-κB and the marker of apoptosis and autophagy (Bnip3), suggesting the ox-LDL was related to inflammation, apoptosis, and autophagy [52]. Here, INS is linked to type 1 diabetes mellitus.