By WB analyzing, in the DM group, the expression of CXCL16, NF-κB, and TF proteins in the pancreas and spleen were raised prominently compared to the control group (p < 0.01), and the degrees of CXCL16, NF-κB, and TF proteins were also huge down-regulated in the Rg1 treatment T1DM mice (p < 0.05) (Figures 8(a)–8(c) and 8(g)–8(i)). This evidence concerns the gene NFKB1 and type 1 diabetes mellitus.