In this study, mice immunized with the TCM-adjuvanted influenza vaccine exhibited significantly higher expression of CD11c+MHC II+, CD11c+CD80+, CD11c+CD86+, and CD3+CD4+, and have a higher proliferation index of T and B cell, compared with mice receiving vaccination alone, indicating that TCM may promote the maturation of DCs and activate innate and adaptive immunity in the immune response of the influenza vaccine. The gene discussed is CD80; the disease is influenza.