FSCN1 and malignant colon neoplasm: In addition, the results of the analyses of a colon cancer cell line model, simultaneously transfected with PTOV1-AS2 overexpression and miR-145-5p mimic plasmids, revealed that miR-145-5p downregulated the protein expression of the target gene FSCN1 and reduced the PTOV1-AS2-induced expression of FSCN1 (Figure 3(f)).