The effect of the major genotypic alterations in each of the three cell lines LNCaP, (AR positive, pTEN null, p53 positive), PC-3 (AR negative, pTEN null, p53 negative), and DU145 (AR negative, pTEN positive, p53 positive) on the PCa protein interactome for each cell line was also examined (Table 2; Supplementary Figure S4). Here, PTEN is linked to posterior cortical atrophy.