Moreover, the nuclei in skeletal muscle fibers from Net39-null mice exhibit significant deformations, changes in chromatin accessibility, and altered gene expression, while human muscle biopsies from patients with Emery Dreifuss muscular dystrophy revealed a downregulation of Net39 (Ramirez-Martinez et al., 2021). Here, PLPP7 is linked to Emery-Dreifuss muscular dystrophy.