VSIR and colorectal carcinoma: In CRC, YTHDF1 has been observed to enhance the protein levels of PD-L1 and VISTA (also known as PD-1 homolog (PD-1H), DD1α, Gi24), and the IgV domain of which shares a sequence homology with both CD28 and B7 families (140), in an m6A dependent manner (135).