Significant progress has been made in understanding the critical role of m6A regulatory proteins involved in many canonical pathways, such as C-MYC, Wnt/β-catenin, PI3K/AKT/mTOR, p53, and epithelial-mesenchymal transition (EMT), which may be potential therapeutic signaling pathways due to their key role in tumor occurrence, migration, proliferation, apoptosis, metastasis, drug resistance, and treatment response. This evidence concerns the gene AKT1 and neoplasm.