For example, Yin’s group has reported that deletion of METTL3 in myeloid cells attenuated the effect of PD-1 blockade in B16 melanoma, and METTL3 KO mice showed increased infiltration of M1/M2-like TAMs and Treg cells in tumor sites compared to control mice (155). The gene discussed is METTL3; the disease is melanoma.