NFKB1 and diffuse large B-cell lymphoma: In addition, somatic CARD11 GOF mutations recur in germinal center B cell-type (GCB) and activated B cell-like (ABC)-diffuse large B cell lymphoma (DLBCL) (30, 31), an aggressive subset of DLBCL (32) characterized by constitutive NF-κB activation (33, 34).