NFKB1 and lymphoma: The recurrent B-lymphoma CARD11 mutations cluster in the CARD and coiled-coil (CC) domains and disrupt the intrinsic ‘auto-inhibited’ conformation of CARD11 (36), uncoupling it from activating signals and causing it to form aggregates with other CARD11 proteins, MALT1 and BCL10, and thus activate NF-κB and AP1/cJUN (31, 36, 37).