OXP stimulated pre-apoptotic exposure of calreticulin (CRT), the post-apoptotic release of high-mobility group box 1 protein (HMGB1), and the secrete of adenosine triphosphate (ATP)(43, 44), which may promote DC cells maturation and antigen presentation to tumor-specific cytotoxic T lymphocytes (44). The gene discussed is HMGB1; the disease is neoplasm.