In line with the previously published reports, our data from lymph-node cells shows that intranasal SARS-CoV-2 infection causes severe lymphopenia in hACE2.Tg mice were characterized by a significant decrease in lymphocytes (CD45+), total T cells (CD3+) cells, T helper cells (CD4+), and cytotoxic T (CD8+) cells (Figures 7A–C). Here, CD4 is linked to lymphopenia.