While exploring the heterogeneity of NK cells, we identified two “conventional” NK subsets (CD127-CD56+CD94+), and a NK-like subset (CD127-CD56-CD94-IKZF3+) that expressed markers of cytotoxicity including IFNG and CCL5. The CD127-NK_like cell population mainly presented in the HCC microenvironment, which was in accord with the results Heinrich et al. This evidence concerns the gene IKZF3 and hepatocellular carcinoma.