To further validate that this survival advantage could be attributable to MerTK inhibition on macrophages in the leukemia microenvironment, we inoculated MLL-ENL or C1498 cells into mice harboring a homozygous Mertk-knockout mutation (Mertk–/–) or their Mertk-wildtype littermates (MertkWT), and leukemia-free survival was monitored. This evidence concerns the gene KMT2A and leukemia.